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Antibiotic Resistance Without Fitness Cost.

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#1 willis



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Posted 18 January 2006 - 12:15 AM

In the majority of studies performed, resistance caused by
target alterations has been found to engender some cost to
fitness (Table 1), but mutants with no measurable costs
have also been observed. One example of a ‘no cost’ resistance
mutation is the 42nd codon AAA (Lys)®AGA (Arg)
substitution of the rpsL gene, responsible for resistance to
high concentrations of streptomycin in S. typhimurium and
other enteric bacteria [7••,8•]. Other substitutions at the same position cause severe reductions in fitness both in
vitro and in mice [7••,12], whereas these rpsL AGA mutations
appear to be selectively neutral and may even confer
a slight advantage over wild type [7••]

How does this find affect the creation evolution debate if at all?

No fitness cost.

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